Surface modified poly(methyl methacrylate) with 1-methyl-2-methacrylamidoethyl phosphorylcholine moiety

A series of poly(methyl methacrylate) [poly(MMA)] microspheres covered with the 1-methyl-2-methacrylamidoethyl phosphorylcholine (MAPC) moiety, poly(M APC-co-MMA), were prepared by emulsifier-free emulsion copolymerization of methyl methacrylate (MMA) and MAPC using potassium peroxodisulfate (KPS) or 2,2'-azobis[2-(imidazolin-2-yl)propane] dihydrochloride (ABIP) as initiato rs. The zeta-potentials of the particles are -72 to -26 mV and 0 to 27 mV f or poly(MAPC-co-MMA) produced by KPS and ABIP, respectively. Poly(MAPC-co-M MA) suppresses the adsorption of albumin, gamma-globulin, and fibrinogen mo re than poly(MMA) as the control. From XPS measurements the MAPC moiety and the fragments of the initiator are located on the surface of the polymer f ilms prepared from poly(MAPC-co-MMA). Egg yolk lecithin adsorbs on the surf ace of the films, and an organized adsorption layer of lipid, i.e., a hydro gel layer with an analogous structure to biomembrane, is formed.