Reduced visual evoked responses in multiple sclerosis patients with optic neuritis: Comparison of functional magnetic resonance imaging and visual evoked potentials

The limited application of functional magnetic resonance imaging (fMRI) for investigations of multiple sclerosis (MS) patients has already shown that deficits of the motor, cognitive and visual systems may be identified by di fferences in the patterns of activation in response to a suitable stimulus. In MS patients with unilateral optic neuritis, the area of activation in t he primary visual cortex, measured by fMRI techniques, is dramatically redu ced in response to stimulation of the affected eye. The latency of the majo r positive component of the visual evoked potential (VEP) recorded upon sti mulation of the affected eye is significantly increased in these patients a s compared to the unaffected eye and normal volunteers. We have found a cor relation between the neural response measured using fMRI and the latency of the VEP. fMRI signal responses have the potential to provide more detailed topographic information relating to functional deficits in MS.