Case report. Cutaneous phaeohyphomycosis caused by Cladosporium oxysporum

The case of a 66-year-old woman with Gushing syndrome and a 1-year history of papulo-nodular lesions on the right leg is reported. Biopsy revealed sep tate hyphae and yeast-like cells in granulomatous dermo-hypodermal lesions. Culture of biopsy fragments on Sabouraud glucose agar without cycloheximid e produced colonies that were olive green on top and greenish black underne ath. On the basis of microscope findings and scanning electron microscopy o bservation of fragments of colonies, a diagnosis of cutaneous phacohyphomyc osis due to Cladosporium oxysporum was made. The patient was initially trea ted with itraconazole, which led to clinical improvement, but mycological r ecovery was obtained after a course of ketoconazole, made necessary by the presence of pituitary adenoma. To our knowledge, this is the first reported case of subcutaneous phacohyphomycosis due to Cl. oxysporum.