Two domains and one RNA: a molecular threesome

Authors
Hughson, FM Schedl, P
Citation
Fm. Hughson et P. Schedl, Two domains and one RNA: a molecular threesome, NAT ST BIOL, 6(6), 1999, pp. 499-502
Citations number
35
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NATURE STRUCTURAL BIOLOGY
ISSN journal
10728368 → ACNP
Volume
6
Issue
6
Year of publication
1999
Pages
499 - 502
Database
ISI
SICI code
1072-8368(199906)6:6<499:TDAORA>2.0.ZU;2-E
Abstract
Structures of the Drosophila Sex-lethal protein with and without bound RNA reveal an unexpected mode of binding in which tripartite interactions betwe en the two RNA-binding domains and the bound RNA generate specific high-aff inity binding.