Current law in the United States authorizes physicians to diagnose brain de
ath by applying generally accepted neurologic criteria for determining loss
of function of the entire brain. This article offers a medical-legal persp
ective on problems that may arise with respect to the determination of brai
n death. These include the possibility of diagnostic error, conceptual disa
greements that may constrain the use of neurologic criteria to diagnose dea
th, and the conflation of brain death and loss of consciousness. This artic
le also addresses legal aspects of the debate over whether to expand the de
finition of brain death to include permanent unconsciousness. Although exis
ting laws draw a clear distinction between brain death and the persistent v
egetative state, many courts have authorized removal of life support from i
ndividuals whose unconsciousness is believed to be permanent on proof that
removal accords with preferences expressed before sentience was lost.