latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant

Authors
Pinto, S Quintana, DG Smith, P Mihalek, RM Hou, ZH Boynton, S Jones, CJ Hendricks, M Velinzon, K Wohlschlegel, JA Austin, RJ Lane, WS Tully, T Dutta, A
Citation
S. Pinto et al., latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant, NEURON, 23(1), 1999, pp. 45-54
Citations number
53
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEURON
ISSN journal
08966273 → ACNP
Volume
23
Issue
1
Year of publication
1999
Pages
45 - 54
Database
ISI
SICI code
0896-6273(199905)23:1<45:LEASOT>2.0.ZU;2-C
Abstract
The Drosophila latheo (lat) gene was identified in a behavioral screen for olfactory memory mutants. The original hypomorphic lat(P1) mutant (Boynton and Tully, 1992) shows a structural defect in adult brain. Homozygous letha l lat mutants lack imaginal discs, show little cell proliferation in the CN S of third instar larvae, and die as early pupae. lat(P1) was cloned, and a ll of the above mentioned defects of hypomorphic or homozygous lethal lat m utants were rescued with a lat(+) transgene. lat encodes a novel protein wi th homology to a subunit of the origin recognition complex (ORC). Human and Drosophila LAT both associate with ORC2 and are related to yeast ORC3, sug gesting that LAT functions in DNA replication during cell proliferation.