CYTOLOGIC FEATURES OF SINUS HISTIOCYTOSIS WITH MASSIVE LYMPHADENOPATHY - A REPORT OF 3 CASES

BACKGROUND: Sinus histiocytosis with massive lymphadenopathy (SHML) wa s described over 20 years ago by Rosai and Dorfman. Originally it was described as occurring in young males, predominantly with cervical lym phadenopathy. Since then over 423 histologically documented cases of S HML have been documented, including many extranodal sites. Few studies have characterized the cytologic features of SHML. CASE: Three cases of lymph node involvement by SHML occurred, one also with skin involve ment. Cytologic findings included numerous histiocytes with phagocytiz ed lymphocytes, atypical forms of histiocytes and a reactive, lymphoid background. Surgical biopsy and immunohistochemical stain for S-100 p rotein of all three cases confirmed the cytologic impression. CONCLUSI ON:Sinus histiocytosis with massive lymphadenopathy can be diagnosed b y cytology in conjunction with clinical history and immunohistochemist ry.