Low-frequency damped electroretinographic wavelets in young asymptomatic patients with dominant retinitis pigmentosa - A new electroretinographic finding

Objective: To describe a previously unreported electroretinographic (ERG) p attern in early retinitis pigmentosa (RP), Design: Two case reports. Participants: Two unrelated young asymptomatic patients with autosomal-domi nant retinitis pigmentosa were studied. Main Outcome Measures: Clinical findings and ERG responses were assessed. Results: Na ERG responses were detected scotopically with low-luminance sti muli, With increasingly brighter stimuli, a series of three to five low-fre quency damped wavelets developed under both scotopic and photopic condition s. The period of the wavelets was 25 to 37 msec. Conclusions: Low-frequency damped ERG, wavelets occur in some young asympto matic patients with autosomal-dominant RP. The ERG pattern suggests that th ese wavelets are predominantly cone-generated.