Giant cell angiofibroma of the orbit and eyelid

Citation
N. Hayashi et al., Giant cell angiofibroma of the orbit and eyelid, OPHTHALMOL, 106(6), 1999, pp. 1223-1229
Citations number
47
Categorie Soggetti
Optalmology,"da verificare
Journal title
OPHTHALMOLOGY
ISSN journal
01616420 → ACNP
Volume
106
Issue
6
Year of publication
1999
Pages
1223 - 1229
Database
ISI
SICI code
0161-6420(199906)106:6<1223:GCAOTO>2.0.ZU;2-L
Abstract
Purpose: To report the clinicopathologic features of a newly recognized tum or, giant cell angiofibroma, Design: Observational case series. Main Outcome Measures: Clinical and histopathologic features of giant cell angiofibroma; Methods: Light and electron microscopy and immunohistochemistry of five cas es of giant cell angiofibroma, Results: A total of five patients (4 women and 1 man) are described: two pr esented with a painless mass in the eyelid, two with a mass in the orbit, a nd one presented with a conjunctival lesion. All lesions were well demarcat ed with no capsule and were composed of blood vessels, a patternless spindl e-shaped cell proliferation with a solid and pseudovascular appearance, and multinucleated giant cells. Both spindle-shaped and giant tumor cells were intensely positive for CD34 and vimentin, Conclusion: Giant cell angiofibroma resembles solitary fibrous tumor and gi ant cell fibroblastoma and should;be considered in the differential diagnos is of spindle-cell tumors in the eyelid, orbit, and conjunctiva.