Plant stanol esters from wood and vegetable oil sources were tested for gen
otoxicity in bacterial (Salmonella typhimurium) and mammalian cell (L5178Y)
gene mutation assays and in a mammalian cell chromosome aberration assay (
CHO cells). The two stanol ester formulations were tested separately at dos
es up to the limit of solubility, with and without the addition of an Arocl
or-induced rat liver microsome metabolic activation system (S9 mix). All te
sts were performed in duplicate and gave negative results for both wood and
vegetable oil stanol ester formulations. Thus, plant stanol esters are not
genotoxic under the conditions of exposure tested. (C) 1999 Academic Press
.