SEQUENTIAL ALPHA-INTERFERON AND TAMOXIFEN - IN-VITRO BIOLOGIC EFFECTSOF 2 GROWTH MODULATORS

Tamoxifen and alpha-interferon have interesting and complementary biol ogic effects which may be relevant for breast cancer growth and regres sion. The hormone responsive cell line MCF-7 was used as a model to st udy the biologic effects of sequential administration of these two age nts. Interferon had a significant antiproliferative effect and increas ed ER and TGF-beta expression. The combination had at least additive a ntiproliferative effects as well as effects on expression of ER, TGF-b eta, c-erbB-2, P24 and Ki67. alpha-IFN modulates TMX induced biologic effects and the sequential administration of alpha-IFN and TMX may lea d to potentially important modulation of biologic endpoints. Further s tudies are appropriate.