ANTIFUNGAL DITERPENOID ALKALOIDS FROM DELPHINIUM-DENUDATUM

The roots of Delphinium denudatum have yielded a new diterpenoid alkal oid, 8-acetylheterophyllisine (1), in addition to the known alkaloids vilmorrianone (2), panicutine (3), denudatine (4), isotalatizidine (5) , and condelphine (6), as well as 3-hydroxy-2-methyl-4H-pyran-4-one (7 ). Compounds 1, 3, and 7 have not been isolated from this plant previo usly. The structures of compounds 1, 3, and 7 were determined through spectral and X-ray diffraction analyses. Compounds 1-3 have shown anti fungal activity against a number of human pathogenic fungi.