IDENTIFICATION OF THE NOVEL ANTIMICROBIAL FATTY-ACID (5Z,9Z)-14-METHYL-5,9-PENTADECADIENOIC ACID IN EUNICEA-SUCCINEA

Authors
CARBALLEIRA NM REYES ED SOSTRE A RODRIGUEZ AD RODRIGUEZ JL GONZALEZ FA
Citation
Nm. Carballeira et al., IDENTIFICATION OF THE NOVEL ANTIMICROBIAL FATTY-ACID (5Z,9Z)-14-METHYL-5,9-PENTADECADIENOIC ACID IN EUNICEA-SUCCINEA, Journal of natural products, 60(5), 1997, pp. 502-504
Citations number
11
Categorie Soggetti
Chemistry,"Plant Sciences","Pharmacology & Pharmacy","Chemistry Medicinal
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
60
Issue
5
Year of publication
1997
Pages
502 - 504
Database
ISI
SICI code
0163-3864(1997)60:5<502:IOTNAF>2.0.ZU;2-A
Abstract
The phospholipid fatty acid composition of Eunicea succinea was invest igated, and the novel (5Z,9Z)-14-methyl-5,9-pentadecadienoic acid was identified. Structural characterization was accomplished by means of m ass spectrometry of its pyrrolidide derivative, NMR, FTIR, and total s ynthesis. Other interesting phospholipid fatty acids in E. succinea we re the tetracosapolyenoic acids 6,9,12,15,18,21-tetracosahexaenoic aci d (24:6) and 6,9,12,15,18-tetracosapentaenoic acid (24:5). The title c ompound was particularly active against Gram-positive bacteria such as Staphylococcus aureus (MIC 0.24 mu mol/mL) and Streptococcus faecalis (MIC 016 mu mol/mL).