SCH-54445 - A NEW POLYCYCLIC XANTHONE WITH HIGHLY POTENT ANTIFUNGAL ACTIVITY PRODUCED BY ACTINOPLANES SP

Authors
CHU M TRUUMEES I MIERZWA R TERRACCIANO J PATEL M LOEBENBERG D KAMINSKI JJ DAS P PUAR MS
Citation
M. Chu et al., SCH-54445 - A NEW POLYCYCLIC XANTHONE WITH HIGHLY POTENT ANTIFUNGAL ACTIVITY PRODUCED BY ACTINOPLANES SP, Journal of natural products, 60(5), 1997, pp. 525-528
Citations number
7
Categorie Soggetti
Chemistry,"Plant Sciences","Pharmacology & Pharmacy","Chemistry Medicinal
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
60
Issue
5
Year of publication
1997
Pages
525 - 528
Database
ISI
SICI code
0163-3864(1997)60:5<525:S-ANPX>2.0.ZU;2-G
Abstract
A novel antifungal agent, Sch 54445, was isolated from the fermentatio n broth of an Actinoplanes species. Sch 54445 was identified as a poly cyclic xanthone related to the albofungin family of compounds on the b asis of analyses of spectroscopic data. As a broad-spectrum antifungal agent, Sch 54445 exhibits highly potent activities against various ye asts and dermatophytes with MIC values similar to 0.000 38 mu g/mL.