M. Chu et al., SCH-54445 - A NEW POLYCYCLIC XANTHONE WITH HIGHLY POTENT ANTIFUNGAL ACTIVITY PRODUCED BY ACTINOPLANES SP, Journal of natural products, 60(5), 1997, pp. 525-528
A novel antifungal agent, Sch 54445, was isolated from the fermentatio
n broth of an Actinoplanes species. Sch 54445 was identified as a poly
cyclic xanthone related to the albofungin family of compounds on the b
asis of analyses of spectroscopic data. As a broad-spectrum antifungal
agent, Sch 54445 exhibits highly potent activities against various ye
asts and dermatophytes with MIC values similar to 0.000 38 mu g/mL.