BRIPIODIONEN, A NEW INHIBITOR OF HUMAN CYTOMEGALOVIRUS PROTEASE FROM STREPTOMYCES SP WC76599

Authors
SHU YZ YE QM KOLB JM HUANG S VEITCH JA LOWE SE MANLY SP
Citation
Yz. Shu et al., BRIPIODIONEN, A NEW INHIBITOR OF HUMAN CYTOMEGALOVIRUS PROTEASE FROM STREPTOMYCES SP WC76599, Journal of natural products, 60(5), 1997, pp. 529-532
Citations number
16
Categorie Soggetti
Chemistry,"Plant Sciences","Pharmacology & Pharmacy","Chemistry Medicinal
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
60
Issue
5
Year of publication
1997
Pages
529 - 532
Database
ISI
SICI code
0163-3864(1997)60:5<529:BANIOH>2.0.ZU;2-A
Abstract
Bripiodionen (1), a new natural product, was isolated from Streptomyce s sp. WC76599 during the screening of microbial fermentation extracts for their ability to inhibit human cytomegalovirus protease. The struc ture of 1 was elucidated by spectroscopic methods. Compound 1 displaye d inhibitory activity against human cytomegalovirus protease with an I C50 value of 30 mu M.