Prediction of single episodes of drinking during the treatment of alcohol-dependent patients

Drinking episodes during the treatment (relapses or lapses) of alcohol-depe ndent patients is predicted from clinical ratings of patients and individua l background data such as alcohol drinking history and social status. The p robability of these relapses (or lapses) is determined up to three days in advance using a logistic regression procedure, The study group consisted of 33 male alcohol-dependent persons, who participated in a treatment program . Clinical ratings were performed three times a week by a trained person du ring a visit to the clinic. The questionnaire contained 23 different items about irritation, craving for alcohol, sleep disturbances, etc. The relapse s were either self-reported or detected by a biochemical marker in a urine sample that was taken daily. The most important factor for a relapse in alc ohol drinking was shown to be if the patient already had had one relapse du ring the treatment. Other important clinical factors were the levels of irr itation and autonomic disturbances. None of the variables measuring mood sh ifts was significant. Family conditions during childhood were the most impo rtant background variables. The predictions turned out to have a rather hig h specificity, but the sensitivity was lower. Half of the relapses were not predicted by an increased probability for relapse. Self-reported relapses were predictable from preceding interviews and were also less frequent comp ared to those detected objectively by the biochemical markers. (C) 1999 Els evier Science Inc. All rights reserved.