Occurrence of allergic conditions in asthmatics with analgesic intolerance

Background: The study aimed to determine whether allergic conditions accomp any analgesic intolerance. Methods: A total of 132 analgesic-intolerant patients with bronchial asthma admitted to the adult allergy unit from January 1991 to October 1997 and 1 03 patients with bronchial asthma randomly selected from among the asthmati cs referred to our department between January and October 1997 were enrolle d in the study. Those having analgesic intolerance and bronchial asthma wer e accepted as group I; patients having only asthma were accepted as group I I. A standard questionnaire was completed for all the patients. Physical ex amination, routine skin prick tests, determination of total IgE levels and blood type, and oral analgesic provocation tests were also performed. Results: The results showed that some allergic conditions were significantl y more common in group 1 (22.7% and 7.8% for food allergy/intolerance [P<0. 05], 16.7% and 7.8% for antibiotic allergy, 16.7% and 2.9% for dermographis m, 9.8% and 1.0% for metal allergy, and 9.1% and 1.0% for chronic urticaria for groups I and II, respectively [P<0.001]). In addition, the mean of the total IgE level in the serum was higher in group I than group II (77.6 and 53.7 IU/ml; P<0.05), and the cumulative analgesic consumption was more in group I (14.2 +/- 17.1 and 9.1 +/- 12.5 boxes; P<0.05). Conclusions: Dermographism; chronic urticaria; antibiotic, metal, and food allergy; high levels of total IgE; and a high amount of cumulative analgesi c consumption may be the conditions accompanying analgesic intolerance in a sthmatics.