Primary antiphospholipid syndrome and cerebral atrophy: A rare association?

Neurologic complications are common in patients with antiphospholipid syndr ome. In this article, we report the case of a young woman with neurologic d isorders, a history of hypertension and transient ischemic attacks, and cer ebral atrophy associated with primary antiphospholipid syndrome (PAPS). Mag netic resonance imaging of the brain showed multiple ischemic lesions and r emarkable atrophy of frontal and parietal lobes. Cerebral atrophy in patien ts with PAPS can be considered as a feature of this disease. The case is di scussed on the basis of relevant past literature. Although there are few re ports on neuroradiologic findings in patients with PAPS, cerebral atrophy h as been described. Because PAPS is more frequently recognized today than in the past, this condition should be included in the differential diagnosis of cerebral atrophy, particularly in young patients.