An in vitro investigation into conformational aspects of gabapentin

Authors
Bryans, JS Horwell, DC Ratcliffe, GS Receveur, JM Rubin, JR
Citation
Js. Bryans et al., An in vitro investigation into conformational aspects of gabapentin, BIO MED CH, 7(5), 1999, pp. 715-721
Citations number
21
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY
ISSN journal
09680896 → ACNP
Volume
7
Issue
5
Year of publication
1999
Pages
715 - 721
Database
ISI
SICI code
0968-0896(199905)7:5<715:AIVIIC>2.0.ZU;2-V
Abstract
Conformational analysis of constrained cyclohexane systems was pioneered fi fty years ago by Barton and Hassel. We now report an investigation based on a conformational analysis of a number of novel cyclohexane based Gabapenti n analogues coupled with their in vitro evaluation at the Gabapentin bindin g site. These data are used to propose a possible binding conformation for Gabapentin. (C) 1999 Elsevier Science Ltd. All rights reserved.