Synthesis of phosphonate 3-phthalidyl esters as prodrugs for potential intracellular delivery of phosphonates

Authors
Dang, Q Brown, BS van Poelje, PD Colby, TJ Erion, MD
Citation
Q. Dang et al., Synthesis of phosphonate 3-phthalidyl esters as prodrugs for potential intracellular delivery of phosphonates, BIOORG MED, 9(11), 1999, pp. 1505-1510
Citations number
10
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
11
Year of publication
1999
Pages
1505 - 1510
Database
ISI
SICI code
0960-894X(19990607)9:11<1505:SOP3EA>2.0.ZU;2-5
Abstract
A new prodrug approach for intracellular delivery of phosphonates was devel oped via the synthesis of 3-phthalidyl esters of 1-naphthalenemethylphospho nate. This approach is advantageous over the traditional acyloxymethyl phos phonate prodrugs, because these prodrugs do not generate formaldehyde and h ave improved plasma half-lives. (C) 1999 Elsevier Science Ltd. All rights r eserved.