Preparation of crystalline P-netrobenzyl 2-formyl carbapenems by oxidativecleavage

Authors
Hsiao, Y Wells, KM Yang, CH Jensen, MS Chung, JYL Yasuda, N Hughes, DL
Citation
Y. Hsiao et al., Preparation of crystalline P-netrobenzyl 2-formyl carbapenems by oxidativecleavage, BIOORG MED, 9(11), 1999, pp. 1559-1562
Citations number
17
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
11
Year of publication
1999
Pages
1559 - 1562
Database
ISI
SICI code
0960-894X(19990607)9:11<1559:POCP2C>2.0.ZU;2-G
Abstract
Crystalline 1 beta-methyl-2-formyl carbapenem pNB esters were prepared by o smium-mediated oxidative cleavage of the corresponding 2-vinyl derivatives. Reduction of the 2-formyl compounds gave the corresponding 2-hydroxymethyl derivatives, which are key intermediates for the anti-MRS carbapenem candi date (1). (C) 1999 Published by Elsevier Science Ltd. All rights reserved.