Lipase-catalyzed protection of the hydroxy groups of the nucleosides inosine and 2 '-deoxyinosine: A new chemoenzymatic synthesis of the antiviral drug 2 ',3 '-dideoxyinosine

Authors
Ciuffreda, P Casati, S Santaniello, E
Citation
P. Ciuffreda et al., Lipase-catalyzed protection of the hydroxy groups of the nucleosides inosine and 2 '-deoxyinosine: A new chemoenzymatic synthesis of the antiviral drug 2 ',3 '-dideoxyinosine, BIOORG MED, 9(11), 1999, pp. 1577-1582
Citations number
12
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
11
Year of publication
1999
Pages
1577 - 1582
Database
ISI
SICI code
0960-894X(19990607)9:11<1577:LPOTHG>2.0.ZU;2-#
Abstract
The selective acylation of the hydroxy groups of the nucleosides inosine la and 2'-deoxyinosine Ib has been achieved in the presence of Candida antarc tica and Pseudomonas sp. lipases in organic solvents; starting from the 5'- acetyl derivative of 2'-deoxyinosine, compound 5a, an efficient chemoenzyma tic synthesis of the antiviral drug 2',3'-dideoxyinosine 1c has been achiev ed, (C) 1999 Elsevier Science Ltd. All rights reserved.