Novel derivatives of 3-(dipropylamino) chroman. Interactions with 5-HT1A and D-2A receptors.

Authors
Caldirola, P Chowdhury, R Unelius, L Mohell, N Hacksell, U Johansson, AM
Citation
P. Caldirola et al., Novel derivatives of 3-(dipropylamino) chroman. Interactions with 5-HT1A and D-2A receptors., BIOORG MED, 9(11), 1999, pp. 1583-1586
Citations number
23
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
11
Year of publication
1999
Pages
1583 - 1586
Database
ISI
SICI code
0960-894X(19990607)9:11<1583:NDO3CI>2.0.ZU;2-0
Abstract
Novel 8-aryl and 8-aroyl substituted derivatives of 3-(dipropylamino)chroma n are described. The compounds have been prepared by a palladium catalyzed reaction of iodoarenes and a stannylated derivative of [eta(6)-3-(dipropyla mino)chroman]Cr(CO)(3). Several of the compounds have high affinity for 5-H T1A receptors whereas the affinity for D-2A receptors is lower, the 8-aryla ted derivatives being slightly more potent than the 8-aroylated analogues. (C) 1999 Elsevier Science Ltd. All rights reserved.