Design of scytalone dehydratase inhibitors as rice blast fungicides: (N-phenoxypropyl)-careoxamides

Authors
Jordan, DB Lessen, TA Wawrzak, Z Bisaha, JJ Gehret, TC Hansen, SL Schwartz, RS Basarab, GS
Citation
Db. Jordan et al., Design of scytalone dehydratase inhibitors as rice blast fungicides: (N-phenoxypropyl)-careoxamides, BIOORG MED, 9(11), 1999, pp. 1607-1612
Citations number
17
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
11
Year of publication
1999
Pages
1607 - 1612
Database
ISI
SICI code
0960-894X(19990607)9:11<1607:DOSDIA>2.0.ZU;2-H
Abstract
Insights gained from a crystal structure of scytalone dehydratase led to th e design of carboxamide inhibitors with a phenoxypropyl group substituted o n the nitrogen atom. Potent enzyme inhibitors were synthesized around this motif, the best of which provided excellent control of rice blast disease i n greenhouse assays and outdoor field trials. (C) 1999 Elsevier Science Ltd . All rights reserved.