Design of scytalone dehydratase inhibitors as rice blast fungicides: Derivatives of norephedrine

Authors
Basarab, GS Jordan, DB Gehret, TC Schwartz, RS Wawrzak, Z
Citation
Gs. Basarab et al., Design of scytalone dehydratase inhibitors as rice blast fungicides: Derivatives of norephedrine, BIOORG MED, 9(11), 1999, pp. 1613-1618
Citations number
13
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
11
Year of publication
1999
Pages
1613 - 1618
Database
ISI
SICI code
0960-894X(19990607)9:11<1613:DOSDIA>2.0.ZU;2-I
Abstract
Five X-ray crystal structures of scytalone dehydratase complexed with diffe rent inhibitors have delineated conformationally flexible regions of the bi nding pocket. This information was used for the design and synthesis of a n orephedrine-derived cyanoacetamide class of inhibitors leading to potent fu ngicides. (C) 1999 Elsevier Science Ltd. All rights reserved.