Gs. Basarab et al., Design of scytalone dehydratase inhibitors as rice blast fungicides: Derivatives of norephedrine, BIOORG MED, 9(11), 1999, pp. 1613-1618
Five X-ray crystal structures of scytalone dehydratase complexed with diffe
rent inhibitors have delineated conformationally flexible regions of the bi
nding pocket. This information was used for the design and synthesis of a n
orephedrine-derived cyanoacetamide class of inhibitors leading to potent fu
ngicides. (C) 1999 Elsevier Science Ltd. All rights reserved.