Aberrant DNA methylation of the p16(INK4a) gene in plasma DNA of breast cancer patients

Authors
Silva, JM Dominguez, G Villanueva, MJ Gonzalez, R Garcia, JM Corbacho, C Provencio, M Espana, P Bonilla, F
Citation
Jm. Silva et al., Aberrant DNA methylation of the p16(INK4a) gene in plasma DNA of breast cancer patients, BR J CANC, 80(8), 1999, pp. 1262-1264
Citations number
31
Categorie Soggetti
Oncology,"Onconogenesis & Cancer Research
Journal title
BRITISH JOURNAL OF CANCER
ISSN journal
00070920 → ACNP
Volume
80
Issue
8
Year of publication
1999
Pages
1262 - 1264
Database
ISI
SICI code
0007-0920(199906)80:8<1262:ADMOTP>2.0.ZU;2-2
Abstract
Hypermethylation of exon 1 of p16(INK4a) was examined in tumour and plasma DNA of a series of breast cancer patients. De novo methylation was observed in the tumours of eight patients (23%), and in plasma DNA in five (14%) of these eight patients. Our data show that de novo methylation of exon 1 of p16(INK4a) can be demonstrated in plasma DNA of breast cancer patients, a f act that provides additional evidence of the tumour-related origin of free plasma DNA in cancer patients.