Chemical modification of chitin and chitosan 1: preparation of partially deacetylated chitin derivatives via a ring-opening reaction with cyclic acidanhydrides in lithium chloride/N,N-dimethylacetamide
Y. Shigemasa et al., Chemical modification of chitin and chitosan 1: preparation of partially deacetylated chitin derivatives via a ring-opening reaction with cyclic acidanhydrides in lithium chloride/N,N-dimethylacetamide, CARBOHY POL, 39(3), 1999, pp. 237-243
Derivatives of partially N-deacetylated chitin (DAC) were prepared via ring
-opening reactions with various cyclic acid anhydrides in lithium chloride/
N,N-dimethylacetamide (LiCl/DMAc) system. Some cyclic acid anhydrides such
as succinic, maleic, glutaric, and phthalic anhydrides gave successfully wa
ter-soluble DAC derivatives. From the enzymatic studies, the glycosyl bond
of succinyl and maleoyl DAC-20 (20% DAC) was rapidly degraded by lysozyme o
r chitinase, though that of phthaloyl DAC-20 was not. The ester linkage of
succinyl DAC-20 was stable against lipase for five days at room temperature
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