Metabolism of some "second"- and "fourth"-generation antidepressants: Iprindole, viloxazine, bupropion, mianserin, maprotiline, trazodone, nefazodone, and venlafaxine

Authors
Rotzinger, S Bourin, M Akimoto, Y Coutts, RT Baker, GB
Citation
S. Rotzinger et al., Metabolism of some "second"- and "fourth"-generation antidepressants: Iprindole, viloxazine, bupropion, mianserin, maprotiline, trazodone, nefazodone, and venlafaxine, CELL MOL N, 19(4), 1999, pp. 427-442
Citations number
127
Categorie Soggetti
Neurosciences & Behavoir
Journal title
CELLULAR AND MOLECULAR NEUROBIOLOGY
ISSN journal
02724340 → ACNP
Volume
19
Issue
4
Year of publication
1999
Pages
427 - 442
Database
ISI
SICI code
0272-4340(199908)19:4<427:MOS"A">2.0.ZU;2-P
Abstract
1. This review summarizes the major known aspects of the metabolism of seco nd-generation (iprindole, viloxazine, bupropion, mianserin, maprotiline, an d trazodone) and fourth-generation (nefazodone and venlafaxine) antidepress ants. 2. Discussions about specific enzymes involved and about possible pharmacok inetic drug-drug interactions, particularly as they relate to cytochrome P4 50 enzymes, are provided.