In recent years, endothelial dysfunction has been identified as an early fe
ature of atherosclerosis. Endothelial function can be measured noninvasivel
y by using brachial artery ultrasound. A variety of factors associated with
atherosclerosis also impair endothelial function. Some of these factors ar
e lipoproteins such as various forms of low-density lipoproteins, postprand
ial chylomicron remnants, fasting triglyceride-rich particles, and free fat
ty acids. A high-fat diet also has an adverse effect on endothelial functio
n Several interventions can improve endothelial function and, at the same t
ime, reduce cardiovascular events; Measuring endothelial function may event
ually serve as a useful index to determine an individual's risk for coronar
y artery disease.