Determinants of SR protein specificity

The SR (Ser-Arg) proteins are a family of nuclear factors that play multipl e important roles in splicing of mRNA precursors in metazoan organisms. fun ctioning in both constitutive and regulated splicing. Certain of these func tions are redundant, such that any single SR proteins will suffice, but oth er functions are unique and are specific to a given family member. A number of studies during the past year have investigated the. basis for SR protei n specificity.