CD1-mediated immune responses to glycolipids

Authors
Burdin, N Kronenberg, M
Citation
N. Burdin et M. Kronenberg, CD1-mediated immune responses to glycolipids, CURR OP IM, 11(3), 1999, pp. 326-331
Citations number
64
Categorie Soggetti
Immunology
Journal title
CURRENT OPINION IN IMMUNOLOGY
ISSN journal
09527915 → ACNP
Volume
11
Issue
3
Year of publication
1999
Pages
326 - 331
Database
ISI
SICI code
0952-7915(199906)11:3<326:CIRTG>2.0.ZU;2-A
Abstract
Major advances have recently been accomplished in understanding the biochem istry of interactions between lipid antigens and CD1. The diversity of lipi d antigens loaded onto CP1 molecules in normal cells, the ligand requiremen ts for CD1 recognition by autoreactive T cells,including NK T cells, and th e significance of CD1-mediated autoreactivity, as opposed to pathogen react ivity, remain controversial issues.