Functions of newly identified members of the tumor necrosis factor receptor ligand superfamilies in lymphocytes

Rapid progress: in the discovery of members of the tumor; necrosis factor r eceptor/ligand superfamilies has been made, mainly with the help of massive DNA sequencing and bioinformatic studies. Biological studies of the new me mbers have not only indicated overlapping roles with other members but also provided insights into novel functions. In particular, multiple pairings: of receptors and ligands highlight a complex control mechanism of immune re sponses by these superfamilies.