Synthesis, physicochemical characterisation and cytotoxic screening of newcomplexes of cerium, lanthanum and neodymium with Warfarin and Coumachlor sodium salts

The complexes of the types Ln(HW)(3). nH(2)O and Ln(HC)(3). nH(2)O [where L n = Ce, La, Nd; HW Warfarin HC Coumachlor] have been synthesized by reactio n of Warfarin Sodium, resp. Coumachlor Sodium and the appropriate lanthanid e nitrates in various stoichiometric ratios. The formation of the complexes have been proved on the basis of elemental analysis, conductivities, IR sp ectroscopy and H-1-NMR spectroscopy It is concluded that the lacton- and th e keto-carbonyl groups of the ligands are bonded to the metal ion as bident ate ligand. The conductivity measurements show non-electrolytic nature of t he complexes. Cytotoxicity determination by MTT-assay shows that the inorga nic salts and the complexes with Warfarin did not show any significant acti vity. The complexes with Coumachlor were found to be more cytotoxic. The mo st active compound was the complex of Cerium with Coumachlor. All tested co mplexes showed similar in vitro cytotoxic profiles. This fact is in agreeme nt with the formation of the complexes. (C) Elsevier, Paris.