Three patients with a chlamydial respiratory tract infection showed signifi
cant titre rises for the three chlamydial micro-immunofluorescence tests, p
erformed with Chlamydia pneumoniae, C. psittaci and C. trachomatis. Such cr
oss-reactions procure an inaccurate discrimination between the various Chla
mydia species which remains speculative anyhow when only a positive serolog
ical profile against one chlamydial subspecies is performed. We consider th
at using the serologic assay as proof for past sexually transmitted C. trac
homatis infection falls outside the limits of prudent interpretation of lab
oratory tests. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.