A new strategy for the asymmetric synthesis of 1,3-oxathiolane-based nucleoside analogues

Authors
Caputo, R Guaragna, A Palumbo, G Pedatella, S
Citation
R. Caputo et al., A new strategy for the asymmetric synthesis of 1,3-oxathiolane-based nucleoside analogues, EUR J ORG C, (6), 1999, pp. 1455-1458
Citations number
23
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
ISSN journal
1434193X → ACNP
Issue
6
Year of publication
1999
Pages
1455 - 1458
Database
ISI
SICI code
1434-193X(199906):6<1455:ANSFTA>2.0.ZU;2-A
Abstract
A ready asymmetric synthesis of 3'-oxathionucleosides has been accomplished in three main steps from benzoyloxyethanal. The synthesis is characterized by high overall yield and considerable enantiomeric excesses. It represent s a general synthetic path to prepare a wide range of heterosubstituted sul fur-containing nucleoside analogues.