Reversal by [D-Ala(2),D-Leu(5)]enkephalin of the dopamine transporter losscaused by methamphetamine

Authors
Tsao, LI Cadet, JL Su, TP
Citation
Li. Tsao et al., Reversal by [D-Ala(2),D-Leu(5)]enkephalin of the dopamine transporter losscaused by methamphetamine, EUR J PHARM, 372(3), 1999, pp. R5-R7
Citations number
8
Categorie Soggetti
Pharmacology & Toxicology
Journal title
EUROPEAN JOURNAL OF PHARMACOLOGY
ISSN journal
00142999 → ACNP
Volume
372
Issue
3
Year of publication
1999
Pages
R5 - R7
Database
ISI
SICI code
0014-2999(19990521)372:3<R5:RB[OTD>2.0.ZU;2-3
Abstract
A single administration of 40 mg/kg (i.p.) of methamphetamine caused a loss of dopamine transporter in the striatum of albino Swiss (CD-1) mouse for a t least 3 weeks. The administration of a single dose of [D-Ala(2),D-Leu(5)] enkephalin (DADLE) (18 mg/kg, i.p.), given at day 14 after the administrati on of methamphetamine, caused a significant, transient restoration of dopam ine transporter level in the striatum. These results suggest that delta-opi oid peptide DADLE is able to reverse the neuronal damage caused by methamph etamine. (C) 1999 Elsevier Science B.V. All rights reserved.