Endometrial development was improved by transdermal estradiol in patients treated with clomiphene citrate

The objective of this study was to examine the effect of transdermal estrog en therapy on the endometrial thickness and serum hormone levels in anovula tory patients treated with clomiphene citrate (CC). There was a significant difference in endometrial thickness between the CC + transdermal estrogen group and the CC only group from day -2 to day +2. Serum estradiol (E-2) le vels in the CC + transdermal estrogen group were significantly higher than those in the CC only group on day -2 and day 0. Our results support that ad dition of transdermal E-2 to the treatment protocol of the women treated wi th CC elicited a favorable response of the endometrium.