New Accl polymorphism in the follicle-stimulating hormone beta-subunit gene and its prevalence in three southeast Asian populations

Authors
Liao, WX Tong, Y Roy, AC Ng, SC
Citation
Wx. Liao et al., New Accl polymorphism in the follicle-stimulating hormone beta-subunit gene and its prevalence in three southeast Asian populations, HUMAN HERED, 49(3), 1999, pp. 181-182
Citations number
6
Categorie Soggetti
Molecular Biology & Genetics
Journal title
HUMAN HEREDITY
ISSN journal
00015652 → ACNP
Volume
49
Issue
3
Year of publication
1999
Pages
181 - 182
Database
ISI
SICI code
0001-5652(1999)49:3<181:NAPITF>2.0.ZU;2-0
Abstract
A thymine-cytosine substitution was identified in exon 3 (codon 76, TAT to TAC) of the human follicle-stimulating hormone (FSH) beta-subunit gene. The nucleotide change led to creation of an Accl digestion site. The frequenci es of the A allele (with Accl site) in Chinese (n = 201), Malays (n = 168) and Indians (n = 132) were 0.358, 0.333 and 0.402, respectively, The new FS H beta-subunit marker may be useful in gene tracking and association studie s.