SIMULTANEOUS DETERMINATION OF ANTIOXIDANTS AND PRESERVATIVES IN COSMETICS AND PHARMACEUTICAL PREPARATIONS BY REVERSED-PHASE HPLC

Authors
GAGLIARDI L DEORSI D MANNA L TONELLI D
Citation
L. Gagliardi et al., SIMULTANEOUS DETERMINATION OF ANTIOXIDANTS AND PRESERVATIVES IN COSMETICS AND PHARMACEUTICAL PREPARATIONS BY REVERSED-PHASE HPLC, Journal of liquid chromatography & related technologies, 20(11), 1997, pp. 1797-1808
Citations number
13
Categorie Soggetti
Chemistry Analytical","Biochemical Research Methods
Journal title
Journal of liquid chromatography & related technologies → ACNP
ISSN journal
10826076
Volume
20
Issue
11
Year of publication
1997
Pages
1797 - 1808
Database
ISI
SICI code
1082-6076(1997)20:11<1797:SDOAAP>2.0.ZU;2-I
Abstract
A high performance liquid chromatographic method for the simultaneous determination of multiple additives in o/w cosmetic and pharmaceutical formulations was developed by using a RP-8 Select B column, a linear gradient elution and UV detection. A very simple extraction procedure was required. The separation obtained for nine antioxidants and seven preservatives was very good under the chromatographic conditions used. Their analysis was carried out in commercial samples and satisfactory results were obtained both far the recovery and the coefficient of va riation.