Isolation and characterization of the Saccharomyces cerevisiae XPT1 gene encoding xanthine phosphoribosyl transferase

Authors
Guetsova, ML Crother, TR Taylor, MW Daignan-Fornier, B
Citation
Ml. Guetsova et al., Isolation and characterization of the Saccharomyces cerevisiae XPT1 gene encoding xanthine phosphoribosyl transferase, J BACT, 181(9), 1999, pp. 2984-2986
Citations number
14
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF BACTERIOLOGY
ISSN journal
00219193 → ACNP
Volume
181
Issue
9
Year of publication
1999
Pages
2984 - 2986
Database
ISI
SICI code
0021-9193(199905)181:9<2984:IACOTS>2.0.ZU;2-Y
Abstract
A new Saccharomyces cerevisiae gene, XPT1, was isolated as a multicopy supp ressor of a hypoxanthine phosphoribosyl transferase (HPRT) defect. Disrupti on of XPT1 affects xanthine utilization in vivo and results in a severe red uction of xanthine phosphoribosyl transferase (XPRT) activity while HPRT is unaffected. We conclude that XPT1 encodes XPRT in yeast.