RIP3, a novel apoptosis-inducing kinase

Citation
Xq. Sun et al., RIP3, a novel apoptosis-inducing kinase, J BIOL CHEM, 274(24), 1999, pp. 16871-16875
Citations number
32
Categorie Soggetti
Biochemistry & Biophysics
Journal title
JOURNAL OF BIOLOGICAL CHEMISTRY
ISSN journal
00219258 → ACNP
Volume
274
Issue
24
Year of publication
1999
Pages
16871 - 16875
Database
ISI
SICI code
0021-9258(19990611)274:24<16871:RANAK>2.0.ZU;2-A
Abstract
RIPS is a novel gene product containing a N-terminal kinase domain that sha res extensive homology with the corresponding domain in RIP (receptor-inter acting protein) and RIPE. Unlike RIP, which has a C-terminal death domain, and RIPE, which has a C-terminal caspase activation and recruitment domain, RIPS has a unique C terminus. RIPS binds RIP through its unique C-terminal segment and by virtue of this interaction is recruited to the tumor necros is factor (TNF) receptor-1 signaling complex. Previous studies have shown t hat RIP mediates TNF-induced activation of the anti-apoptotic NF-KB pathway . RIPS, however, attenuates both RIP and TNF receptor-1-induced NF-KB activ ation. Overexpression studies revealed RIPS to be a potent inducer of apopt osis, capable of selectively binding to large prodomain initiator caspases.