Tri-n-octyl[P-32]phosphine oxide. Synthesis and biodistribution via the hepatic artery of rats

Authors
Fortineau, AD Brichory, F Pellen, P Sai, C Dazord, L Mortier, J Vaultier, M Bourguet, P
Citation
Ad. Fortineau et al., Tri-n-octyl[P-32]phosphine oxide. Synthesis and biodistribution via the hepatic artery of rats, J LABEL C R, 42(6), 1999, pp. 527-536
Citations number
26
Categorie Soggetti
Chemistry & Analysis","Inorganic & Nuclear Chemistry
Journal title
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
ISSN journal
03624803 → ACNP
Volume
42
Issue
6
Year of publication
1999
Pages
527 - 536
Database
ISI
SICI code
0362-4803(199906)42:6<527:TOSABV>2.0.ZU;2-8
Abstract
The purpose of this study was to analyse the biodistribution of tri-n-octyl [P-32]phosphine oxide ([P-32]TOPO) in rats following intrahepatic arterial injection so as to assess its potential as a radiopharmaceutical for the tr eatment of hepatic tumours in humans, The retention of [P-32]TOPO remained high in liver and decreased rapidly in kidney, bone marrow and blood, The s ynthesis of [P-32]TOPO was performed in a one step procedure from [P-32]POC l3 and n-octyl magnesium chloride in diethyl ether at 0 degrees C.