Non-peptide fibrinogen receptor antagonists. 4(1). The synthesis of [H-3]L-756,568.

Authors
Hamill, TG Hutchinson, JH Brashear, KM Hartman, GD
Citation
Tg. Hamill et al., Non-peptide fibrinogen receptor antagonists. 4(1). The synthesis of [H-3]L-756,568., J LABEL C R, 42(6), 1999, pp. 605-609
Citations number
9
Categorie Soggetti
Chemistry & Analysis","Inorganic & Nuclear Chemistry
Journal title
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
ISSN journal
03624803 → ACNP
Volume
42
Issue
6
Year of publication
1999
Pages
605 - 609
Database
ISI
SICI code
0362-4803(199906)42:6<605:NFRA4T>2.0.ZU;2-P
Abstract
The synthesis of [H-3]L-756,568, an orally active fibrinogen receptor antag onist, is described. Two synthetic pathways were developed using either bro moindoles 2a/2b or bromoaryl sulfonamide 11 as the precursor. Use of the br omoaryl sulfonamide precursor led to [H-3]L-756,568 with higher radiochemic al purity, higher radiochemical yield, and slightly higher specific activit y.