Acute myo-inositol enhances swimming activity in goldfish

Inositol in concentrations of 1-4Mm (but not the control condition: mannito l-glucose) administered in aquarium water showed enhancement of swimming ac tivity of goldfish after acute treatment (5 hours). These data support simi lar findings in rats. These data suggest that inositol may enhance motor ac tivity which may be of relevance in neuropsychiatric disorders. Future stud ies of the effects of lithium on this activity, and its potential reversal by inositol may shed light on the possible involvement of the phosphatidyl- inositol second messenger system in this behavior.