M. Al-yamany et al., Spontaneous remission of primary central nervous system lymphoma: report of 3 cases and discussion of pathophysiology, J NEURO-ONC, 42(2), 1999, pp. 151-159
Primary central nervous system lymphoma (PCNSL) is a relatively uncommon di
sease in which spontaneous remission is exceedingly rare. We are reporting
three cases of primary CNS lymphoma with spontaneous regression in two to e
ight weeks, from the time of the initial diagnosis. The remission lasted fo
r four years in the first case, two years in the second, and one year in th
e third case. Tissue diagnosis was made in the first two cases after relaps
e, and in the third case a biopsy was done at the initial presentation. The
literature and the possible pathophysiological mechanisms of this interest
ing phenomenon are discussed.