Spontaneous remission of primary central nervous system lymphoma: report of 3 cases and discussion of pathophysiology

Primary central nervous system lymphoma (PCNSL) is a relatively uncommon di sease in which spontaneous remission is exceedingly rare. We are reporting three cases of primary CNS lymphoma with spontaneous regression in two to e ight weeks, from the time of the initial diagnosis. The remission lasted fo r four years in the first case, two years in the second, and one year in th e third case. Tissue diagnosis was made in the first two cases after relaps e, and in the third case a biopsy was done at the initial presentation. The literature and the possible pathophysiological mechanisms of this interest ing phenomenon are discussed.