Postoperative radiotherapy for supratentorial malignant gliomas

From January 1988 to December 1996, sixty-five patients with histologically confirmed supratentorial malignant gliomas were treated with postoperative radiation therapy in our department. They were subjected to this analysis according to different clinical and pathologic parameters. The overall 1-ye ar, 2-year survival rate was 57% and 23%, respectively. With univariate ana lysis, age, postoperative Karnofsky performance status, duration of symptom s, multiplicity of lesions and the extent of surgery were identified as sig nificant prognostic factors. With multivariate analysis, postoperative Karn ofsky performance status and the extent of surgery continued to show indepe ndent prognostic significance on overall survival.