Regulation of the UNC-18-Caenorhabditis elegans syntaxin complex by UNC-13

Authors
Sassa, T Harada, S Ogawa, H Rand, JB Maruyama, IN Hosono, R
Citation
T. Sassa et al., Regulation of the UNC-18-Caenorhabditis elegans syntaxin complex by UNC-13, J NEUROSC, 19(12), 1999, pp. 4772-4777
Citations number
42
Categorie Soggetti
Neurosciences & Behavoir
Journal title
JOURNAL OF NEUROSCIENCE
ISSN journal
02706474 → ACNP
Volume
19
Issue
12
Year of publication
1999
Pages
4772 - 4777
Database
ISI
SICI code
0270-6474(19990615)19:12<4772:ROTUES>2.0.ZU;2-9
Abstract
The Caenorhabditis elegans unc-13, unc-18, and unc-64 genes are required fo r normal synaptic transmission. The UNC-18 protein binds to the unc-64 gene product C. elegans syntaxin (Ce syntaxin). However, it is not clear how th is protein complex is regulated. We show that UNC-13 transiently interacts with the UNC-18-Ce syntaxin complex, resulting in rapid displacement of UNC -18 from the complex. Genetic and biochemical evidence is presented that UN C-13 contributes to the modulation of the interaction between UNC-18 and Ce syntaxin.