D. Groshar et al., Renal function after tumor enucleation: Assessment by quantitative SPECT of Tc-99m-dimercaptosuccinic acid uptake by the kidneys, J NUCL MED, 40(6), 1999, pp. 968-971
Citations number
26
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging","Medical Research Diagnosis & Treatment
The purpose of this study was to evaluate the amount of functioning. renal-
mass removed and the amount of remaining individual renal function after tu
mor enucleation. Methods: Renal functional volume, percentage injected dose
(%ID) per cubic centimeter of renal tissue and individual renal uptake of
24 operated and 24 contralateral kidneys were studied by two sequential SPE
CT quantitations of Tc-99m-dimercaptosuccinic acid (DMSA) uptake by the kid
neys (QDMSA). The first study was before surgery and the second study was 1
to 6 mo (mean 3.5 mo) after surgery. Mean tumor size was 3.4 +/- 0.99 cm a
nd all tumors were confined to the renal parenchyma (stages pT1 and pT2). R
esults: In the operated kidneys, there was a statistically significant decr
ease in renal cortical volume (170 +/- 46 mL after surgery versus 207 +/- 4
5 mL before surgery, t = 6.2, P < 0.001) and individual renal uptake (10.3%
+/- 3.0% after surgery versus 13.0% +/- 2.9% before surgery, t = 5.4, P <
0.001). There was no statistically significant change after surgery compare
d with before surgery in the %ID per cubic centimeter of renal tissue of th
e operated kidneys, and in the volume, %ID per cubic centimeter and uptake
of the contralateral normal kidneys. Conclusion: The results suggest that Q
DMSA is a noninvasive method able to assess changes in separate renal funct
ion. The limited functioning parenchymal loss after tumor enucleation had n
o effect on the opposite kidneys.