STRUCTURE-BASED DESIGN OF NOVEL, DIPEPTIDE LIGANDS TARGETING THE PP60(SRC) SH2 DOMAIN

Authors
SHAHRIPOUR A PARA KS PLUMMER MS LUNNEY EA HOLLAND DR RUBIN JR HUMBLET C FERGUS JH MARKS JS SALTIEL AR SAWYER TK
Citation
A. Shahripour et al., STRUCTURE-BASED DESIGN OF NOVEL, DIPEPTIDE LIGANDS TARGETING THE PP60(SRC) SH2 DOMAIN, Bioorganic & medicinal chemistry letters, 7(9), 1997, pp. 1107-1112
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
9
Year of publication
1997
Pages
1107 - 1112
Database
ISI
SICI code
0960-894X(1997)7:9<1107:SDONDL>2.0.ZU;2-4
Abstract
Based on the X-ray structures of the pp60(Src) (Src) SH2 domain comple xed with two high affinity phosphopeptide ligands (Glu-Pro-Gln-pTyr-Gl u-Glu-Ile-Pro-Ile-Tyr-Leu, and Ac-pTyr-Glu-(D) under bar-Hcy-NH2; Hcy = homocyclohexylalanine), we report herein the design and structure-ac tivity relationships of a series of novel dipeptide ligands targeting the Src SH2 domain. (C) 1997 Elsevier Science Ltd.