CYCLIC HOMOPENTAPEPTIDES .1. ANALOGS OF TUBERACTINOMYCINS AND CAPREOMYCIN WITH ACTIVITY AGAINST VANCOMYCIN-RESISTANT ENTEROCOCCI AND PASTEURELLA

Authors
DIRLAM JP BELTON AM BIRSNER NC BROOKS RR CHANG SP CHANDRASEKARAN RY CLANCY J CRONIN BJ DIRLAM BP FINEGAN SM FROSHAUER SA GIRARD AE HAYASHI SF HOWE RJ KANE JC KAMICKER BJ KAUFMAN SA KOLOSKO NL LEMAY MA LINDE RG LYSSIKATOS JP MACLELLAND CP MAGEE TV MASSA MA MILLER SA MINICH ML PERRY DA PETITPAS JW REESE CP SEIBEL SB SU WG SWEENEY KT WHIPPLE DA YANG BV
Citation
Jp. Dirlam et al., CYCLIC HOMOPENTAPEPTIDES .1. ANALOGS OF TUBERACTINOMYCINS AND CAPREOMYCIN WITH ACTIVITY AGAINST VANCOMYCIN-RESISTANT ENTEROCOCCI AND PASTEURELLA, Bioorganic & medicinal chemistry letters, 7(9), 1997, pp. 1139-1144
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
9
Year of publication
1997
Pages
1139 - 1144
Database
ISI
SICI code
0960-894X(1997)7:9<1139:CH.AOT>2.0.ZU;2-Q
Abstract
A 6a-(3',4'-dichlorophenylamino) analog of viomycin was uncovered by a high-throughput screen against the animal health pathogen Pasteurella haemolytica, and has served as a novel lead structure for our infecti ous disease programs. We report herein the synthesis and activity of a nalogs of tuberactinomycins and capreomycin that are active against Pa steurella spp., methicillin-resistant Staphylococcus aureus, and vanco mycin-resistant enterococci. (C) 1997 Elsevier Science Ltd.